This therapeutic approach needs validating in a clinical trial with the strategy of identification of TG and treatment according to TT for each patient independently of their prior diagnosis.ĬOPD asthma overlap airflow obstruction biomarker personalised medicine. In this special article, a group of experts provides their perspective and proposes approaching the treatment of chronic airway disease (CAD) through the identification of a series of therapeutic goals (TG) linked to treatable traits (TT) - understood as clinical, physiological, or biological characteristics that are quantifiable using biomarkers.
This has generated the description of new mixed or overlapping disease phenotypes with no clear biological grounds.
14 Pneumology Service, Son Espases University Hospital, IdISBa, CIBERES, Clínica Quirón-Rotger, Palma, Spain.Ĭhronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. 13 Pneumology Service, Hospital Arnau de Vilanova, Valencia, Spain. 12 Pneumology Service and Faculty of Medicine, Hospital Clínico San Carlos, Complutense University of Madrid, Madrid, Spain. 11 Pneumology Service, Hospital de Laredo, Laredo, Spain. 
10 Pneumology Service, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz De Tenerife, Spain. 9 Division of Respirology and Sleep Medicine, Queen's University, Canada, ON, Canada. 8 Pneumology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 7 Faculty of Medicine at the University of Santiago de Compostela, Pneumology Service of the University Clinical Hospital of Santiago de Compostela, CIBERES, Santiago de Compostela, Spain. 6 Pneumology Service, Hospital Universitario Dr Peset, Valencia, Spain. 5 Pneumology Service, Ramón y Cajal Hospital (Ramon y Cajal Health Research Institute, IRYCIS), Madrid, Spain. 4 Pneumology Service, La Princesa University Hospital, Madrid, Research Institute La Princesa IIP, Madrid, Spain. 3 Pneumology Service, Hospital Universitario Virgen del Rocio, Seville, Spain. 2 Pneumology Service, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBERES, Barcelona, Spain. 1 Pneumology Service, University Hospital Lucus Augusti, Lugo, EOXI Cervo, Lugo, Monforte, Spain.
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